Pigment Epithelium-Derived Factor as a New Predictor of Mortality Among Chronic Kidney Disease Patients Treated With Hemodialysis

Hiroyuki Terawaki, Sho Ichi Yamagishi, Yoichi Funakoshi, Yukie Matsuyama, Tomoyoshi Terada, Keisuke Nakayama, Makoto Ogura, Tatsuo Hosoya, Sadayoshi Ito, Seiichi Era, Masaaki Nakayama

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Pigment epithelium-derived factor (PEDF) plays a protective role against atherosclerosis. Although serum PEDF level is increased in patients undergoing regular hemodialysis (HD), the pathophysiological role of PEDF in HD patients is unknown. We measured serum PEDF levels in 74 HD patients, and the association between serum PEDF and adverse events such as all-cause death and cardiovascular accident was evaluated prospectively. During the follow up of 45.4±25.1 months, 24 patients (32.4%) experienced cardiovascular accident and 18 (24.3%) died. Significantly higher incidences of all-cause mortality and cardiovascular accident were observed in the lower PEDF group than in the higher PEDF group. After adjusting for propensity score calculated from multiple confounding factors (age, gender, systolic blood pressure, history of previous cardiovascular disease, level of carbonyl content, albumin, hemoglobin, total cholesterol, creatinine, C-reactive protein, dialysis vintage, Kt/V-urea and history of diabetes), lower predialytic PEDF was a significant risk factor for all-cause mortality (relative hazard=6.060, standard error=0.68467, P=0.0085). Lower levels of predialytic PEDF was associated with an increased risk of mortality.

Original languageEnglish
Pages (from-to)625-630
Number of pages6
JournalTherapeutic Apheresis and Dialysis
Volume17
Issue number6
DOIs
Publication statusPublished - 2013 Dec

Keywords

  • Cardiovascular disease
  • Hemodialysis
  • Mortality
  • Oxidative stress
  • Pigment epithelium-derived factor

ASJC Scopus subject areas

  • Hematology
  • Nephrology

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