Physiological effects and tissue distribution from large doses of tocotrienol in rats

Akira Shibata, Kiyotaka Nakagawa, Hitoshi Shirakawa, Teiko Kobayashi, Yuki Kawakami, Rie Takashima, Ai Ohashi, Shoko Sato, Yusuke Ohsaki, Fumiko Kimura, Toshiyuki Kimura, Tsuyoshi Tsuduki, Michio Komai, Teruo Miyazawa

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Supplementation to an AIN93G-based diet of tocotrienol (T3) for 13 weeks administered to Fischer 344/ slc rats showed a safety profile with no side effects. Dosedependent T3 levels were detected in many tissues. Under the present experimental conditions, a continuous intake of the T3 concentrate would be safe in the rats as long as the T3 content was less than 0.20% of the dietary intake.

Original languageEnglish
Pages (from-to)1805-1808
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume76
Issue number9
DOIs
Publication statusPublished - 2012

Keywords

  • Large dose
  • Rat
  • Tissue distribution
  • Tocopherol
  • Tocotrienol

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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