Physicochemical analysis of nucleobase-metal interactions.

Yoshiyuki Tanaka, Atsushi Toyozawa, Yoshinori Kondo

Research output: Contribution to journalArticlepeer-review


It is important to know what kinds of chemical bonds are formed between metal ions and nucleic acids. We have studied metal-nucleobase interactions, by using NMR spectroscopy in solution. For the accurate understanding, we tried measurement at low temperature below -30 degrees C. To avoid freezing of the solution, we have extensively searched solution conditions which is suitable for measurements at low temperature, and found several possible conditions. One was the condition which contained H2O and cryoprotectant at low pH for guanosine-5'-monophosphate--Cd(II), system, the other was the mixed solvent of dimethyl sulfoxide and N,N-dimethylformamide for guanosine--Cd(II) system.

Original languageEnglish
Pages (from-to)187-188
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number2
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Medicine(all)


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