Physical properties and blood compatibility of surface-modified segmented polyurethane by semi-interpenetrating polymer networks with a phospholipid polymer

Nobuyuki Morimoto, Yasuhiko Iwasaki, Nobuo Nakabayashi, Kazuhiko Ishihara

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Segmented polyurethanes, (SPU)s, are widely used in the biomedical fields because of their excellent mechanical property. However, when blood is in contact with the SPU, non-specific biofouling on the SPU occurs which reduces its mechanical property. To obtain novel blood compatible elastomers, the surface of the SPU was modified with 2-methacryloyloxyethyl phosphorylcholine (MPC) by forming a semi-interpenetrating polymer network (semi-IPN). The SPU film modified by MPC polymer with the semi-IPN (MS-IPN film) was prepared by visible light irradiation of the SPU film in which the monomers were diffused. X-ray photoelectron spectroscopy confirmed that the MPC units were exposed on the MS-IPN film surface. The mechanical properties of the MS-IPN film characterized by tensile testing were similar to those of the SPU film. Platelet adhesion on MS-IPN films was also investigated before and after stress loading to determine the effects of the surface modification on the blood compatibility. Many platelets did adhere on the SPU film before and after stress loading. On the other hand, the MS-IPN film prevented platelet adhesion even after repeated stress loading.

Original languageEnglish
Pages (from-to)4881-4887
Number of pages7
JournalBiomaterials
Volume23
Issue number24
DOIs
Publication statusPublished - 2002 Dec 1
Externally publishedYes

Keywords

  • 2-Methacryloyloxyethyl phosphorylcholine polymer
  • Blood compatibility
  • Interpenetrating polymer networks
  • Segmented polyurethane
  • Stress loading

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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