TY - JOUR
T1 - Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease
AU - Tanaka, Rie
AU - Sugiura, Hisatoshi
AU - Yamada, Mitsuhiro
AU - Ichikawa, Tomohiro
AU - Koarai, Akira
AU - Fujino, Naoya
AU - Yanagisawa, Satoru
AU - Onodera, Katsuhiro
AU - Numakura, Tadahisa
AU - Sato, Kei
AU - Kyogoku, Yorihiko
AU - Sano, Hirohito
AU - Yamanaka, Shun
AU - Okazaki, Tatsuma
AU - Tamada, Tsutomu
AU - Miura, Motohiko
AU - Takahashi, Tsuneyuki
AU - Ichinose, Masakazu
N1 - Funding Information:
This study was supported by grants from the Japan Society for the Promotion of Science (grant number: #16H05307, #16K15453, #17H04180) and a grant from the Practical Research Project for Allergic Diseases and Immunology from Japan Agency for Medical Research and Development, AMED (grant number: #16ek0410018h0002, #16ek040036h0001, #17ek0410036h0002).
PY - 2018/4/24
Y1 - 2018/4/24
N2 - Background: Growth differentiation factor 11 (GDF11) is reported to possess anti-aging and rejuvenating effects, including muscle regeneration and to be highly expressed in skeletal muscle. Recently, we demonstrated that the levels of plasma GDF11 were decreased in COPD. However, the effect of decreased circulating GDF11 in the pathophysiology of COPD remains unknown. The aim of this study is to investigate the association between the plasma GDF11 levels and various clinical parameters in patients with COPD. Patients and methods: Eighteen ex-smokers as control subjects and 70 COPD patients participated in the current study. We measured the levels of plasma GDF11 using immunoblotting, lung function, physical activity using a triaxial accelerometer, quadriceps strength, exercise capacity, and systemic inflammatory markers. We investigated the association between the levels of plasma GDF11 and these clinical parameters. Results: The levels of plasma GDF11 in the COPD patients had significant positive correlations with the data of lung function. Furthermore, the levels of plasma GDF11 were significantly correlated with the physical activity, quadriceps strength, and exercise capacity. Moreover, the levels of plasma GDF11 were significantly correlated with the data of inflammatory markers. Although various factors were related to GDF11, the multiple regression analysis showed that physical activity was significantly associated with the levels of plasma GDF11. Conclusion: Physical inactivity was significantly related to the decreased GDF11 levels in COPD, which might be useful for understanding the pathogenesis of COPD. Clarifying the relationships between the physical inactivity and GDF11 may reveal a potentially attractive therapeutic approach in COPD via increasing the plasma levels of GDF11.
AB - Background: Growth differentiation factor 11 (GDF11) is reported to possess anti-aging and rejuvenating effects, including muscle regeneration and to be highly expressed in skeletal muscle. Recently, we demonstrated that the levels of plasma GDF11 were decreased in COPD. However, the effect of decreased circulating GDF11 in the pathophysiology of COPD remains unknown. The aim of this study is to investigate the association between the plasma GDF11 levels and various clinical parameters in patients with COPD. Patients and methods: Eighteen ex-smokers as control subjects and 70 COPD patients participated in the current study. We measured the levels of plasma GDF11 using immunoblotting, lung function, physical activity using a triaxial accelerometer, quadriceps strength, exercise capacity, and systemic inflammatory markers. We investigated the association between the levels of plasma GDF11 and these clinical parameters. Results: The levels of plasma GDF11 in the COPD patients had significant positive correlations with the data of lung function. Furthermore, the levels of plasma GDF11 were significantly correlated with the physical activity, quadriceps strength, and exercise capacity. Moreover, the levels of plasma GDF11 were significantly correlated with the data of inflammatory markers. Although various factors were related to GDF11, the multiple regression analysis showed that physical activity was significantly associated with the levels of plasma GDF11. Conclusion: Physical inactivity was significantly related to the decreased GDF11 levels in COPD, which might be useful for understanding the pathogenesis of COPD. Clarifying the relationships between the physical inactivity and GDF11 may reveal a potentially attractive therapeutic approach in COPD via increasing the plasma levels of GDF11.
KW - COPD
KW - Muscle strength
KW - Physical activity
KW - Rejuvenating factor
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U2 - 10.2147/COPD.S157035
DO - 10.2147/COPD.S157035
M3 - Article
C2 - 29731621
AN - SCOPUS:85046148755
VL - 13
SP - 1333
EP - 1342
JO - International Journal of COPD
JF - International Journal of COPD
SN - 1176-9106
ER -