Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor β and γ chains

Nobuyuki Tanaka, Hironobu Asao, Kazuyuki Ohbo, Naoto Ishii, Toshikazu Takeshita, Masataka Nakamura, Hidetada Sasaki, Kazuo Sugamura

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

The functional interleukin 2 (IL-2) receptors contain the β and γ chains which are necessary for the transduction of cell growth signals. Monoclonal antibodies specific for the β chain and γ chain coimmunoprecipitated JAK1 and 114-kDa JAK2 tyrosine kinases, respectively. Tyrosine phosphorylation of JAK1 and JAK2 was induced upon IL-2 stimulation, and IL-2 activated the JAK2 kinase. These results demonstrate that the JAK1 and JAK2 tyrosine kinases are physically associated with the β chain and γ chain, respectively, and suggest that regulation of the kinases may be linked to IL-2-induced signal transduction.

Original languageEnglish
Pages (from-to)7271-7275
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume91
Issue number15
DOIs
Publication statusPublished - 1994 Jul 19

ASJC Scopus subject areas

  • General

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