Phylogeny of regulatory regions of vertebrate tyrosinase genes.

H. Yamamoto, T. Kudo, N. Masuko, H. Miura, S. Sato, M. Tanaka, S. Tanaka, S. Takeuchi, S. Shibahara, T. Takeuchi

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Highly homologous DNA elements were found to be shared by the upstream regions of the mouse tyrosinase and tyrosinase related protein (TRP-1) genes. Several nuclear proteins were shown to bind to both of these upstream regions. Shared homologous DNA elements were also found in the 5' flanking sequences of Japanese quail and snapping turtle tyrosinase genes. Shared homologous nucleotide sequences were found to be scattered like an archipelago in the 5' upstream regions of mouse and human tyrosinase genes. Comparisons between Japanese quail and snapping turtle tyrosinase genes gave similar results. On the contrary, mammalian (mouse and human) and nonmammalian (quail and snapping turtle) tyrosinase genes did not show significant homology in their 5' upstream regions. In contrast, coding sequences in the first exons of vertebrate tyrosinase genes and their deduced amino acid sequences were found to be highly conserved except for their putative leader sequence-coding regions.

Original languageEnglish
Pages (from-to)284-294
Number of pages11
JournalPigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society
Issue number5 Pt 2
Publication statusPublished - 1992 Nov

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Plant Science
  • Cell Biology
  • Clinical Biochemistry
  • Developmental Biology


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