Photophysical investigations of squaraine and cyanine dyes and their interaction with bovine serum albumin

M. Saikiran, D. Sato, S. S. Pandey, T. Kato

Research output: Contribution to journalConference article

1 Citation (Scopus)

Abstract

A model far-red sensitive symmetrical squaraine dye (SQ-3) and unsymmetrical near infra-red sensitive cyanine dye (UCD-1) bearing direct-COOH functionalized indole ring were synthesized, characterized and subjected to photophysical investigations including their interaction with bovine serum albumin (BSA) as a model protein in phosphate buffer solution (PBS). Both of the dyes exhibit strong interaction with BSA in phosphate buffer with high apparent binding constant. A judicious tuning of hydrophobic main backbone with reactive functionality for associative interaction with active site of BSA has been found to be necessary for BSA detection in PBS.

Original languageEnglish
Article number012012
JournalJournal of Physics: Conference Series
Volume704
Issue number1
DOIs
Publication statusPublished - 2016 Apr 19
EventIndia-Japan Expert Group Meeting on Biomolecular Electronics and Organic Nanotechnology for Environment Preservation, IJEGMBE 2015 - Fukuoka, Japan
Duration: 2015 Dec 232015 Dec 26

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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