Abstract
A model far-red sensitive symmetrical squaraine dye (SQ-3) and unsymmetrical near infra-red sensitive cyanine dye (UCD-1) bearing direct-COOH functionalized indole ring were synthesized, characterized and subjected to photophysical investigations including their interaction with bovine serum albumin (BSA) as a model protein in phosphate buffer solution (PBS). Both of the dyes exhibit strong interaction with BSA in phosphate buffer with high apparent binding constant. A judicious tuning of hydrophobic main backbone with reactive functionality for associative interaction with active site of BSA has been found to be necessary for BSA detection in PBS.
| Original language | English |
|---|---|
| Article number | 012012 |
| Journal | Journal of Physics: Conference Series |
| Volume | 704 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2016 Apr 19 |
| Event | India-Japan Expert Group Meeting on Biomolecular Electronics and Organic Nanotechnology for Environment Preservation, IJEGMBE 2015 - Fukuoka, Japan Duration: 2015 Dec 23 → 2015 Dec 26 |
ASJC Scopus subject areas
- Physics and Astronomy(all)
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Saikiran, M., Sato, D., Pandey, S. S., & Kato, T. (2016). Photophysical investigations of squaraine and cyanine dyes and their interaction with bovine serum albumin. Journal of Physics: Conference Series, 704(1), [012012]. https://doi.org/10.1088/1742-6596/704/1/012012