Photoinduced phospholipid polymer grafting on Parylene film: Advanced lubrication and antibiofouling properties

Tatsuro Goda, Tomohiro Konno, Madoka Takai, Kazuhiko Ishihara

Research output: Contribution to journalArticlepeer-review

101 Citations (Scopus)

Abstract

Poly(p-xylylene) (Parylene C) coatings have been applied in implantable electronic devices because of their electrical insulation and moisture barrier properties. To provide lubrication and an antibiofouling surface, a biomimetic phospholipid polymer - poly(2-methacryloyloxyethyl phosphorylcholine (MPC)) - was grafted from the surface using UV irradiation with benzophenone as an initiator. The poly(MPC) grafting on the Parylene C films was confirmed by attenuated total reflection-Fourier transfer inflated irradiation, X-ray photoelectron spectroscopy and ellipsometry. These analyses indicated that the Parylene C films were completely covered by the poly(MPC)-graft layer with an average thickness of 140 nm under dry condition. The atomic force microscope (AFM) images revealed that the poly(MPC)-graft chains extended under wet condition. However, they formed globular structures under dry condition. Water contact angle measurements revealed a decreased receding angle of 29.5° on the poly(MPC)-grafted surface with a high hysteresis of 41.4°. These results indicate that the poly(MPC)-graft chains gain mobility in a wet environment. The average kinetic friction coefficient of the poly(MPC)-grafted surface in water was 0.018, which was 90% lower than that of the original surface. The in vitro single protein adsorption reduced by over 70% due to the poly(MPC) grafting. The hydrated poly(MPC)-graft chains are considered to provide lubrication and antibiofouling properties. The surface zeta potential measurement clarified the electroneutrality of the poly(MPC)-grafted surface. We concluded that the poly(MPC) grafting from the Parylene C layer significantly improved its surface properties and, subsequently, its biological properties.

Original languageEnglish
Pages (from-to)67-73
Number of pages7
JournalColloids and Surfaces B: Biointerfaces
Volume54
Issue number1
DOIs
Publication statusPublished - 2007 Jan 15
Externally publishedYes

Keywords

  • Lubrication
  • Parylene
  • Phosphorylcholine
  • Photografting
  • Protein adsorption

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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