Photofunctional nanomodulators for bioexcitation

Eijiro Miyako, Julie Russier, Matteo Mauro, Cristina Cebrian, Hiromu Yawo, Cécilia Ménard-Moyon, James A. Hutchison, Masako Yudasaka, Sumio Iijima, Luisa De Cola, Alberto Bianco

    Research output: Contribution to journalArticle

    43 Citations (Scopus)

    Abstract

    A single organism comprises diverse types of cells. To acquire a detailed understanding of the biological functions of each cell, comprehensive control and analysis of homeostatic processes at the single-cell level are required. In this study, we develop a new type of light-driven nanomodulator comprising dye-functionalized carbon nanohorns (CNHs) that generate heat and reactive oxygen species under biologically transparent near-infrared (NIR) laser irradiation. By exploiting the physicochemical properties of the nanohorns, cellular calcium ion flux and membrane currents were successfully controlled at the single-cell level. In addition, the nanomodulator allows a remote bioexcitation of tissues during NIR laser exposure making this system a powerful tool for single-cell analyses and innovative cell therapies.

    Original languageEnglish
    Pages (from-to)13121-13125
    Number of pages5
    JournalAngewandte Chemie - International Edition
    Volume53
    Issue number48
    DOIs
    Publication statusPublished - 2014 Nov 24

    Keywords

    • Biological activity
    • Laser chemistry
    • Nanomaterials
    • Nanotechnology

    ASJC Scopus subject areas

    • Catalysis
    • Chemistry(all)

    Fingerprint Dive into the research topics of 'Photofunctional nanomodulators for bioexcitation'. Together they form a unique fingerprint.

  • Cite this

    Miyako, E., Russier, J., Mauro, M., Cebrian, C., Yawo, H., Ménard-Moyon, C., Hutchison, J. A., Yudasaka, M., Iijima, S., De Cola, L., & Bianco, A. (2014). Photofunctional nanomodulators for bioexcitation. Angewandte Chemie - International Edition, 53(48), 13121-13125. https://doi.org/10.1002/anie.201407169