Photofunctional nanomodulators for bioexcitation

Eijiro Miyako, Julie Russier, Matteo Mauro, Cristina Cebrian, Hiromu Yawo, Cécilia Ménard-Moyon, James A. Hutchison, Masako Yudasaka, Sumio Iijima, Luisa De Cola, Alberto Bianco

    Research output: Contribution to journalArticlepeer-review

    54 Citations (Scopus)


    A single organism comprises diverse types of cells. To acquire a detailed understanding of the biological functions of each cell, comprehensive control and analysis of homeostatic processes at the single-cell level are required. In this study, we develop a new type of light-driven nanomodulator comprising dye-functionalized carbon nanohorns (CNHs) that generate heat and reactive oxygen species under biologically transparent near-infrared (NIR) laser irradiation. By exploiting the physicochemical properties of the nanohorns, cellular calcium ion flux and membrane currents were successfully controlled at the single-cell level. In addition, the nanomodulator allows a remote bioexcitation of tissues during NIR laser exposure making this system a powerful tool for single-cell analyses and innovative cell therapies.

    Original languageEnglish
    Pages (from-to)13121-13125
    Number of pages5
    JournalAngewandte Chemie - International Edition
    Issue number48
    Publication statusPublished - 2014 Nov 24


    • Biological activity
    • Laser chemistry
    • Nanomaterials
    • Nanotechnology

    ASJC Scopus subject areas

    • Catalysis
    • Chemistry(all)


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