Photocontrol of Polypeptide Helix Sense by Cis-Trans Isomerism of Side-Chain Azobenzene Moieties

Akihiko Ueno, Keiko Takahashi, Junichi Anzai, Tetsuo Osa

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

The effect of light on polypeptide conformation was investigated by circular dichroism measurements on a series of copolymers composed of β-benzyl L-aspartate and β-(m-phenylazo)benzyl L-aspartate, dissolved in the mixed solvents of 1,2-dichloroethane (DCE) and trimethyl phosphate (TMP). The dark-adapted (trans) copolymers are all left-handed helices in DCE and undergo a conformational change from a left-handed helix to a right-handed helix with an increase in the amount of TMP in the solutions. Photoisomerization of the side-chain azobenzene moieties from trans to cis isomers also causes helix reversal in these copolymers at adequate solvent compositions. These copolymers exhibit CD bands in the regions of azobenzene n-π* and π-π* transitions which change their CD signs corresponding to the helix reversal.

Original languageEnglish
Pages (from-to)6410-6415
Number of pages6
JournalJournal of the American Chemical Society
Volume103
Issue number21
DOIs
Publication statusPublished - 1981 Jan 1

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Fingerprint Dive into the research topics of 'Photocontrol of Polypeptide Helix Sense by Cis-Trans Isomerism of Side-Chain Azobenzene Moieties'. Together they form a unique fingerprint.

Cite this