Abstract
Light-switchable peptide: The combination of cyclization and a photocleavable amino acid provides a potentially versatile strategy for the photocontrol of peptide function. Upon photoirradiation, photoactivatable cyclic matrix metalloproteinase-3 inhibitor peptide (MMPI) was degraded to give the corresponding linear product (see scheme), which showed 47-fold stronger activity than the parent cyclic MMPI.
| Original language | English |
|---|---|
| Pages (from-to) | 1694-1698 |
| Number of pages | 5 |
| Journal | ChemBioChem |
| Volume | 12 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2011 Jul 25 |
| Externally published | Yes |
Keywords
- Cleavage reactions
- Cyclization
- Inhibitors
- Peptides
- Photolysis
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Organic Chemistry
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Cite this
Umezawa, N., Noro, Y., Ukai, K., Kato, N., & Higuchi, T. (2011). Photocontrol of Peptide Function: Backbone Cyclization Strategy with Photocleavable Amino Acid. ChemBioChem, 12(11), 1694-1698. https://doi.org/10.1002/cbic.201100212