Abstract
Light-switchable peptide: The combination of cyclization and a photocleavable amino acid provides a potentially versatile strategy for the photocontrol of peptide function. Upon photoirradiation, photoactivatable cyclic matrix metalloproteinase-3 inhibitor peptide (MMPI) was degraded to give the corresponding linear product (see scheme), which showed 47-fold stronger activity than the parent cyclic MMPI.
Original language | English |
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Pages (from-to) | 1694-1698 |
Number of pages | 5 |
Journal | ChemBioChem |
Volume | 12 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2011 Jul 25 |
Externally published | Yes |
Keywords
- Cleavage reactions
- Cyclization
- Inhibitors
- Peptides
- Photolysis
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Organic Chemistry