Abstract
The solid-state EZ-isomerizability of α,β-unsaturated amides, which had low isomerizability in the solid state, was greatly improved by modifying their structure; EZ-isomerizability was attained by replacing the carbonyl group of the amides by a thiocarbonyl group as well as replacing the heterochiral N-substituent of the amides by a homochiral one. Crystallographic analyses have revealed that the isomerizability of α,β-unsaturated amides and thioamides in the solid state partially depends on their molecular conformation in crystal. In addition, it was found that the packing coefficient has a correlation with the isomerizability; a smaller value of the packing coefficient caused an increased formation of (Z)-isomers.
Original language | English |
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Pages (from-to) | 779-784 |
Number of pages | 6 |
Journal | Bulletin of the Chemical Society of Japan |
Volume | 69 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1996 Mar |
ASJC Scopus subject areas
- Chemistry(all)