Phospholipid polymerhydrogel using the photocrosslinking to fabricate the enzyme immobilizing membrane

Jim Yamaguchi, Tomohiro Konno, Madoka Takai, Kazuhiko Ishihara

Research output: Contribution to conferencePaperpeer-review

Abstract

We synthesized new polymers, which have both photocrosslinkability and biocompatibility by a random copolymerization of 4-(4-methoxycinnamoyl)phenyl methacrylate and 2-methacryloyloxyethyl phosphorylcholine(MPC). These polymers were used as a prepolymer to make a hydrogel by photoirradiation. A gelation began by 5 sec-photoirradiation and it reached equilibrium state after 360 sec-photoirradiation. The absorption maximum at 347 nm, attributed by the cinnamoyl group disappears with the photoirradiation time. That is, the dimerization between cinnamoyl groups in the polymer was proceeded and formed hydrogel. The equilibrium water content of the hydrogels was more than 90%. Moreover, we succeeded to make micro shape hydrogel on a glass by photoirradiation through a photomask. The window shaped of the photomask is transferred to the hydrogel formed. We concluded that these photocrosslinkable polymers are useful for preparing microfluidic devices to separate or immobilize the biomolecules and cells.

Original languageEnglish
Number of pages1
Publication statusPublished - 2006
Externally publishedYes
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: 2006 May 242006 May 26

Other

Other55th SPSJ Annual Meeting
CountryJapan
CityNagoya
Period06/5/2406/5/26

Keywords

  • Biocompatibility
  • Hydrogels
  • Microfuluidic device
  • Phospholipids
  • Photocrosslinking polymer

ASJC Scopus subject areas

  • Engineering(all)

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