Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis

Yuuki Iida, Eiji Sunami, Hiroharu Yamashita, Masaya Hiyoshi, Soichiro Ishihara, Hironori Yamaguchi, Asuka Inoue, Kumiko Makide, Nelson H. Tsuno, Junken Aoki, Joji Kitayama, Toshiaki Watanabe

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Background: The function of phosphatidylserinespecific phospholipase A1 (PS-PLA1), a phospholipase that acts specifically on phosphatidylserine and produces lyso-phosphatidylserine, a lysophospholipid mediator, has not been fully elucidated. We evaluated the role of PS-PLA1 in oncogenesis and metastasis of colorectal cancer (CRC). Materials and Methods: Specimens from 85 patients with CRC were immunostained with a monoclonal antibody against PS-PLA1. The correlation between PS-PLA1 expression and the clinicopathological variables was analyzed. Results: Tumor depth and hematogenous metastasis independently positively correlated with PS-PLA1 expression. High PS-PLA1 expression was associated with shorter disease-free survival, although it was not an independent predictive factor. Conclusion: PS-PLA1 expression in CRC is associated with tumor invasion and metastasis.

Original languageEnglish
Pages (from-to)1459-1464
Number of pages6
JournalAnticancer research
Volume35
Issue number3
Publication statusPublished - 2015 Mar 1

Keywords

  • Colorectal cancer
  • Immunohistochemistry
  • Metastasis
  • Phosphati-dylserine-specific phospholipase A<inf>1</inf>
  • Tumor invasion

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis'. Together they form a unique fingerprint.

Cite this