Abstract
The effects of phenytoin and its major metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro. Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture. This effect may be the cause of phenytoin-induced bone loss in vivo.
Original language | English |
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Pages (from-to) | 82-84 |
Number of pages | 3 |
Journal | Japanese Journal of Pharmacology |
Volume | 82 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2000 |
Keywords
- Bone resorption
- Calvaria
- Phenytoin
ASJC Scopus subject areas
- Pharmacology