Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria

Atsushi Takahashi; Kenji Onodera; Hisashi Shinoda; Hideaki Mayanagi

doi:10.1254/jjp.82.82

Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria

Atsushi Takahashi, Kenji Onodera, Hisashi Shinoda, Hideaki Mayanagi

Special Clinical Facilities

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

The effects of phenytoin and its major metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro. Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture. This effect may be the cause of phenytoin-induced bone loss in vivo.

Original language	English
Pages (from-to)	82-84
Number of pages	3
Journal	Japanese Journal of Pharmacology
Volume	82
Issue number	1
DOIs	https://doi.org/10.1254/jjp.82.82
Publication status	Published - 2000

Keywords

Bone resorption
Calvaria
Phenytoin

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1254/jjp.82.82

Cite this

@article{6f8ea619525442c0a262590eb50a4146,

title = "Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria",

abstract = "The effects of phenytoin and its major metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro. Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture. This effect may be the cause of phenytoin-induced bone loss in vivo.",

keywords = "Bone resorption, Calvaria, Phenytoin",

author = "Atsushi Takahashi and Kenji Onodera and Hisashi Shinoda and Hideaki Mayanagi",

year = "2000",

doi = "10.1254/jjp.82.82",

language = "English",

volume = "82",

pages = "82--84",

journal = "Japanese Journal of Pharmacology",

issn = "0021-5198",

publisher = "Japanese Pharmacological Society",

number = "1",

}

TY - JOUR

T1 - Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria

AU - Takahashi, Atsushi

AU - Onodera, Kenji

AU - Shinoda, Hisashi

AU - Mayanagi, Hideaki

PY - 2000

Y1 - 2000

N2 - The effects of phenytoin and its major metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro. Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture. This effect may be the cause of phenytoin-induced bone loss in vivo.

AB - The effects of phenytoin and its major metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro. Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture. This effect may be the cause of phenytoin-induced bone loss in vivo.

KW - Bone resorption

KW - Calvaria

KW - Phenytoin

UR - http://www.scopus.com/inward/record.url?scp=0033964065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033964065&partnerID=8YFLogxK

U2 - 10.1254/jjp.82.82

DO - 10.1254/jjp.82.82

M3 - Article

C2 - 10874595

AN - SCOPUS:0033964065

VL - 82

SP - 82

EP - 84

JO - Japanese Journal of Pharmacology

JF - Japanese Journal of Pharmacology

SN - 0021-5198

IS - 1

ER -

Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this