Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria

Atsushi Takahashi, Kenji Onodera, Hisashi Shinoda, Hideaki Mayanagi

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

The effects of phenytoin and its major metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro. Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture. This effect may be the cause of phenytoin-induced bone loss in vivo.

Original languageEnglish
Pages (from-to)82-84
Number of pages3
JournalJapanese Journal of Pharmacology
Volume82
Issue number1
DOIs
Publication statusPublished - 2000

Keywords

  • Bone resorption
  • Calvaria
  • Phenytoin

ASJC Scopus subject areas

  • Pharmacology

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