Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria

Atsushi Takahashi; Kenji Onodera; Hisashi Shinoda; Hideaki Mayanagi

doi:10.1254/jjp.82.82

Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria

Atsushi Takahashi, Kenji Onodera, Hisashi Shinoda, Hideaki Mayanagi

Special Clinical Facilities

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

The effects of phenytoin and its major metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro. Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture. This effect may be the cause of phenytoin-induced bone loss in vivo.

Original language	English
Pages (from-to)	82-84
Number of pages	3
Journal	Japanese Journal of Pharmacology
Volume	82
Issue number	1
DOIs	https://doi.org/10.1254/jjp.82.82
Publication status	Published - 2000

Keywords

Bone resorption
Calvaria
Phenytoin

ASJC Scopus subject areas

Pharmacology

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AU - Shinoda, Hisashi

AU - Mayanagi, Hideaki

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