Phenylboronic acid monolayer-modified electrodes sensitive to ribonucleosides

Kazunori Ishizuka, Shigehiro Takahashi, Jun Ichi Anzai

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The surface of a gold (Au) disk electrode was modified with a self-assembled monolayer consisting of phenyl-boronic acid residue to prepare a ribonucleoside-sensitive electrode. The cyclic voltammetric response of the modified electrode to [Fe(CN)6]3- ion dissolved in the sample solution was found to be dependent of the type of ribonucleoside and its concentration. In other words, the peak current in the cyclic voltammogram of [Fe(CN)6]3- ion was significantly decreased when uridine or cytidine was added in the working buffer, while the response to thymidine, 2'-deoxyuridine, and 2'-deoxycytidine was rather small. The voltammetric response was rationalized on the basis of the electrostatic repulsion between [Fe(CN)6]3- ion and the negatively-charged electrode surface, which originates from the addition of OH- ion on the electrode as a result of the formation of phenylboronic acid-ribonucleoside conjugate on the surface of the monolayer.

Original languageEnglish
Pages (from-to)688-690
Number of pages3
JournalElectrochemistry
Volume74
Issue number8
DOIs
Publication statusPublished - 2006 Aug

Keywords

  • Phenylboronic Acid
  • Ribonucleoside Sensor
  • Self-assembled Monolayer

ASJC Scopus subject areas

  • Electrochemistry

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