Phenotyping CYP3A4 and CYP3A5 in pediatrie populations by liquid chromatography/tandem mass spectrometry

Anita Tilve, Santosh Tilve, Naiyu Zheng, Ye Tian, Tomoyuki Oe, Peter C. Adamson, Jeffrey L. Galinkin, Ian A. Blair

Research output: Contribution to conferencePaperpeer-review

Abstract

The CYP3A4 and CYP3A5 phenotype in pediatric populations for subsequent correlations with the patient's genotype was investigated. Reversed-phase chromatography was performed using a Waters Alliance 2690 HPLC system. The synthesis of stable isotope labeled midazolam was carried out in seven steps. This assay will be particularly useful for examining the functional consequences of the variant and wild type CYP3A4 genotype.

Original languageEnglish
Pages593-594
Number of pages2
Publication statusPublished - 2002 Dec 1
Externally publishedYes
EventProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States
Duration: 2002 Jun 22002 Jun 6

Other

OtherProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
CountryUnited States
CityOrlando, FL
Period02/6/202/6/6

ASJC Scopus subject areas

  • Spectroscopy

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