Phase I trial of weekly docetaxel in elderly patients with non-small cell lung cancer

Akira Inoue, Hideo Kunitoh, Kiyoshi Mori, Tohishiro Nukiwa, Masahiro Fukuoka, Nagahiro Saijo

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Recent experience with weekly administration of docetaxel has demonstrated less myelotoxicity and suggested that this regimen holds promise for elderly patients at the high risk of myelosuppression. However, in this phase I trial of weekly docetaxel conducted only in elderly patients (70 years old or more) with non-small cell lung cancer (NSCLC), the toxicity profile was markedly different from that in previous reports. The dose-limiting toxicities were neutropenia, diarrhea and infection, all of which were observed at a dose of 30 mg/m2/week and the maximum-tolerated dose by protocol definition was 30 mg/m2/week. Although other hematological and non-hematological toxicities observed in this treatment were generally moderate and were well tolerated by elderly patients with NSCLC, the risk of myelosuppression still requires careful attention.

Original languageEnglish
Pages (from-to)205-209
Number of pages5
JournalLung Cancer
Volume38
Issue number2
DOIs
Publication statusPublished - 2002 Nov 1
Externally publishedYes

Keywords

  • Chemotherapy
  • Docetaxel
  • Elderly
  • Non-small cell lung cancer
  • Phase I
  • Weekly

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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