Aiming at a multidisciplinary tumor treatment with thermal and chemical mechanisms, the effect of phase change nanodroplets (PCNDs) on inducing reactive chemical species through cavitation was evaluated in vitro. By using the reaction yield of the oxidation of iodide ions to tri-iodide ions as a measure, the effect of PCNDs and PCND-derived microbubbles were investigated. The presence of PCNDs reduced the intensity threshold for chemical reaction by at least 40%. Furthermore, the threshold with PCND-derived microbubbles was 5 times lower than that with PCNDs alone. The interval of exposing the phase change trigger, which is used to generate microbubbles from PCNDs, was found to be shorter than 0.01 s for efficient induction of a chemical reaction. The reaction yields were independent of PCND concentration, thus PCND-derived microbubbles are not considered to work directly in the generation of chemical species undergoing the reaction.
ASJC Scopus subject areas
- Physics and Astronomy(all)