Pharmacological characterization of micropatterned cardiac myocytes

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25 Citations (Scopus)

Abstract

The cardiac myocytes patterned on a single cell level were prepared by microcontact printing, and the response to chemical stimuli was studied using confocal fluorescent Ca2+ imaging. The patterned myocytes were found to conjugate by forming gap junction. It was confirmed for the patterned myocytes that gap junction communication was reversibly inhibited by 1-octanol, but activated by caffeine. Localized stimulation with chemicals was also attempted using a microinjection system for the myocyte patterns formed by single cell alignment. This research was carried out with the objective of developing a bioassay system based on a cellular network.

Original languageEnglish
Pages (from-to)4239-4244
Number of pages6
JournalBiomaterials
Volume24
Issue number23
DOIs
Publication statusPublished - 2003 Oct

Keywords

  • Cardiomyocyte
  • Cell adhesion
  • Fibronectin
  • Micropatterning
  • Polydimethylsiloxane

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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