TY - JOUR
T1 - Pharmacokinetic study of a gallium-porphyrin photo- and sono-sensitizer, ATX-70, in tumor-bearing mice
AU - Sasaki, Kazuaki
AU - Yumita, Nagahiko
AU - Nishigaki, Ryuichiro
AU - Sakata, Isao
AU - Nakajima, Susumu
AU - Umemura, Shin Ichiro
PY - 2001
Y1 - 2001
N2 - The tissue distribution of a gallium-porphyrin photo- and sono-sensitizer,7,12-bis(1-decyloxy-ethyl)-Ga(III)-3,8,13,17- tetramethylporphyrin-2,18-dipropionyldiaspartic acid, ATX-70, was pharmacokinetically examined in tumor-bearing mice. The drug was administered intravenously to CDF1 mice implanted with Colon 26 carcinoma. Blood and tissue samples were collected for up to 72 h after administration. The drug concentration was determined by high-performance liquid chromatography (HPLC) with fluorescence detection. ATX-70 was found to accumulate in tumors at a relatively high concentration that peaked between 2 h and 6 h after administration. However, modest concentration of ATX-70 also remained in healthy tissues for up to 6 h. We examined the distribution of ATX-70 in the tumor in comparison with other tissues from the viewpoint of minimizing possible side effects of laser or ultrasound exposure while maintaining the treatment effect. About 24 h after administration, the tumor/plasma concentration ratio peaked, and relatively high tumor/skin and tumor/muscle concentration ratios were seen.
AB - The tissue distribution of a gallium-porphyrin photo- and sono-sensitizer,7,12-bis(1-decyloxy-ethyl)-Ga(III)-3,8,13,17- tetramethylporphyrin-2,18-dipropionyldiaspartic acid, ATX-70, was pharmacokinetically examined in tumor-bearing mice. The drug was administered intravenously to CDF1 mice implanted with Colon 26 carcinoma. Blood and tissue samples were collected for up to 72 h after administration. The drug concentration was determined by high-performance liquid chromatography (HPLC) with fluorescence detection. ATX-70 was found to accumulate in tumors at a relatively high concentration that peaked between 2 h and 6 h after administration. However, modest concentration of ATX-70 also remained in healthy tissues for up to 6 h. We examined the distribution of ATX-70 in the tumor in comparison with other tissues from the viewpoint of minimizing possible side effects of laser or ultrasound exposure while maintaining the treatment effect. About 24 h after administration, the tumor/plasma concentration ratio peaked, and relatively high tumor/skin and tumor/muscle concentration ratios were seen.
KW - ATX-70
KW - Colon 26
KW - Pharmacokinetics
KW - Photodynamic therapy
KW - Sonodynamic therapy
UR - http://www.scopus.com/inward/record.url?scp=0034791508&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034791508&partnerID=8YFLogxK
U2 - 10.1111/j.1349-7006.2001.tb01190.x
DO - 10.1111/j.1349-7006.2001.tb01190.x
M3 - Article
C2 - 11572768
AN - SCOPUS:0034791508
VL - 92
SP - 989
EP - 995
JO - Cancer Science
JF - Cancer Science
SN - 1347-9032
IS - 9
ER -
