Pharmacokinetic study of a gallium-porphyrin photo- and sono-sensitizer, ATX-70, in tumor-bearing mice

Kazuaki Sasaki, Nagahiko Yumita, Ryuichiro Nishigaki, Isao Sakata, Susumu Nakajima, Shin Ichiro Umemura

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

The tissue distribution of a gallium-porphyrin photo- and sono-sensitizer,7,12-bis(1-decyloxy-ethyl)-Ga(III)-3,8,13,17- tetramethylporphyrin-2,18-dipropionyldiaspartic acid, ATX-70, was pharmacokinetically examined in tumor-bearing mice. The drug was administered intravenously to CDF1 mice implanted with Colon 26 carcinoma. Blood and tissue samples were collected for up to 72 h after administration. The drug concentration was determined by high-performance liquid chromatography (HPLC) with fluorescence detection. ATX-70 was found to accumulate in tumors at a relatively high concentration that peaked between 2 h and 6 h after administration. However, modest concentration of ATX-70 also remained in healthy tissues for up to 6 h. We examined the distribution of ATX-70 in the tumor in comparison with other tissues from the viewpoint of minimizing possible side effects of laser or ultrasound exposure while maintaining the treatment effect. About 24 h after administration, the tumor/plasma concentration ratio peaked, and relatively high tumor/skin and tumor/muscle concentration ratios were seen.

Original languageEnglish
Pages (from-to)989-995
Number of pages7
JournalJapanese Journal of Cancer Research
Volume92
Issue number9
DOIs
Publication statusPublished - 2001

Keywords

  • ATX-70
  • Colon 26
  • Pharmacokinetics
  • Photodynamic therapy
  • Sonodynamic therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Pharmacokinetic study of a gallium-porphyrin photo- and sono-sensitizer, ATX-70, in tumor-bearing mice'. Together they form a unique fingerprint.

Cite this