Pharmacokinetic and pharmacodynamic properties of biapenem, a carbapenem antibiotic, in rat experimental model of severe acute pancreatitis

Yuko Muto, Yukio Mikami, Shiro Sakakibara, Atsuyuki Shimizu, Masashi Niida, Hiroshi Kataoka, Fumi Ito, Katsuyoshi Suzuki, Koji Kijima, Kazunori Maebashi, Toshihiko Takata, Muneo Hikida, Kazunori Takeda, Michiaki Unno

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Objectives: It is known that prophylaxis with imipenem reduces the risk of infection accompanying severe acute pancreatitis. In this study, we modified a rat experimental model of severe acute pancreatitis for antibiotic evaluation, and the effect of biapenem was compared with that of imipenem to determine the usefulness of biapenem. Methods: Severe acute pancreatitis was induced by 5% sodium taurocholate. Antibiotics were subcutaneously administered at 3 and 6 hours and evaluated at 12 hours after the pancreatitis induction. For pharmacokinetic evaluation, antibiotics were subcutaneously administered at 3 hours after the pancreatitis induction. Results: From 3 hours after the induction, bacteria were detected from the pancreas. The total bacterial count increased in a timedependent manner for 12 hours. Biapenem administration reduced the total bacterial count in the pancreas, as observed in imipenem administration. The plasma concentration of biapenem was almost equivalent to that of imipenem; however, the pancreatic penetration of biapenem was approximately twice that of imipenem in this model. Conclusions: Biapenem was suggested to be effective in prophylactic treatment of infectious complications as much as imipenem because of its superior penetration to the pancreas in severe acute pancreatitis.

Original languageEnglish
Pages (from-to)125-132
Number of pages8
JournalPancreas
Volume36
Issue number2
DOIs
Publication statusPublished - 2008 Mar

Keywords

  • Biapenem
  • Carbapenem
  • Imipenem
  • Pancreatic concentration
  • Severe acute pancreatitis

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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