Pharmacogenetics of hormone replacement therapy for climacteric symptoms

Chikari Takeo, Kanako Ugai, Jungo Araki, Ling Zhang, Masanori Baba, Wataru Ohashi, Koichi Ueno, Yoichi Suzuki, Keiko Amano, Aizan Hirai, Masaaki Muramatsu

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Hormone replacement therapy (HRT) is highly effective for women suffering from climacteric symptoms, with occasionally severe side effects. To determine which women needs HRT for climacteric symptoms indeed, pharmacogenetical approach for HRT was performed. Under the condition of minimal HRT, 33 patients required HRT for more than 1 year and the remaining 156 did not. Three single nucleotide polymorphisms (SNPs) in estrogen receptor α (ERα) gene and 3 SNPs and a microsatellite polymorphism in estrogen receptor β (ERβ) gene were analyzed using LightTyper and PCR. Homozygous for 18 CA repeats of D14S1026 (OR 8.00, 95% CI 2.56-25.02, P < 0.001) and rs1256049 (OR 6.35, 95% CI 2.38-16.92, P = 0.004) in ERβ associated with minimal HRT. In contrast, rs1271572 in 789 bp upstream region of ERβ (OR 0.30, 95% CI 0.14-0.65, P = 0.002) gene decreased HRT. rs2228480 in ERα gene also increased HRT. Tailored decisions can be expected on the future use of HRT referring genetic polymorphisms of individuals.

Original languageEnglish
Pages (from-to)604-608
Number of pages5
JournalBiochemical and biophysical research communications
Volume374
Issue number4
DOIs
Publication statusPublished - 2008 Oct 3

Keywords

  • Climacteric symptoms
  • Estrogen receptor α (ERα)
  • Estrogen receptor β (ERβ)
  • Hormone replacement therapy (HRT)
  • Menopause
  • Microsatellite
  • Pharmacogenetics
  • Polymorphism
  • Psychological symptoms
  • Vasomotor symptoms

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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