Layer-by-layer (LbL) deposited thin films composed of poly(methacrylic acid) (PMAA) and poly(amide amine) dendrimer (PAMAM) were prepared and pH-induced decomposition was studied using a quartz crystal microbalance (QCM). The PMAA/PAMAM LbL films can be successfully prepared in the acidic solutions through hydrogen bonding and electrostatic interactions as driving forces. The LbL films are decomposed upon exposure to pH 5.5 or more basic solutions due to electrostatic repulsion between the carboxylate anions in PMAA and PAMAM. The usefulness of the thin films as pH-sensitive organic coatings in developing biosensors and drug delivery systems is suggested.
- Carboxyl-terminated dendrimer
- Drug delivery
- Poly(methacrylic acid)
- pH-sensitive films
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electrical and Electronic Engineering