pH-sensitive thin films compose of poly(methacrylic acid) and carboxyl-terminated dendrimer

Shigeru Tomita, Katsuhiko Sato, Jun Ichi Anzai

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Layer-by-layer (LbL) deposited thin films composed of poly(methacrylic acid) (PMAA) and poly(amide amine) dendrimer (PAMAM) were prepared and pH-induced decomposition was studied using a quartz crystal microbalance (QCM). The PMAA/PAMAM LbL films can be successfully prepared in the acidic solutions through hydrogen bonding and electrostatic interactions as driving forces. The LbL films are decomposed upon exposure to pH 5.5 or more basic solutions due to electrostatic repulsion between the carboxylate anions in PMAA and PAMAM. The usefulness of the thin films as pH-sensitive organic coatings in developing biosensors and drug delivery systems is suggested.

Original languageEnglish
Pages (from-to)250-252
Number of pages3
JournalSensor Letters
Volume6
Issue number1
DOIs
Publication statusPublished - 2008 Feb 1

Keywords

  • Biosensor
  • Carboxyl-terminated dendrimer
  • Drug delivery
  • Poly(methacrylic acid)
  • pH-sensitive films

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering

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