pH-sensitive thin films compose of poly(methacrylic acid) and carboxyl-terminated dendrimer

Shigeru Tomita; Katsuhiko Sato; Jun Ichi Anzai

doi:10.1166/sl.2008.019

pH-sensitive thin films compose of poly(methacrylic acid) and carboxyl-terminated dendrimer

Shigeru Tomita, Katsuhiko Sato, Jun Ichi Anzai

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Layer-by-layer (LbL) deposited thin films composed of poly(methacrylic acid) (PMAA) and poly(amide amine) dendrimer (PAMAM) were prepared and pH-induced decomposition was studied using a quartz crystal microbalance (QCM). The PMAA/PAMAM LbL films can be successfully prepared in the acidic solutions through hydrogen bonding and electrostatic interactions as driving forces. The LbL films are decomposed upon exposure to pH 5.5 or more basic solutions due to electrostatic repulsion between the carboxylate anions in PMAA and PAMAM. The usefulness of the thin films as pH-sensitive organic coatings in developing biosensors and drug delivery systems is suggested.

Original language	English
Pages (from-to)	250-252
Number of pages	3
Journal	Sensor Letters
Volume	6
Issue number	1
DOIs	https://doi.org/10.1166/sl.2008.019
Publication status	Published - 2008 Feb 1

Keywords

Biosensor
Carboxyl-terminated dendrimer
Drug delivery
Poly(methacrylic acid)
pH-sensitive films

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Electrical and Electronic Engineering

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10.1166/sl.2008.019

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abstract = "Layer-by-layer (LbL) deposited thin films composed of poly(methacrylic acid) (PMAA) and poly(amide amine) dendrimer (PAMAM) were prepared and pH-induced decomposition was studied using a quartz crystal microbalance (QCM). The PMAA/PAMAM LbL films can be successfully prepared in the acidic solutions through hydrogen bonding and electrostatic interactions as driving forces. The LbL films are decomposed upon exposure to pH 5.5 or more basic solutions due to electrostatic repulsion between the carboxylate anions in PMAA and PAMAM. The usefulness of the thin films as pH-sensitive organic coatings in developing biosensors and drug delivery systems is suggested.",

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T1 - pH-sensitive thin films compose of poly(methacrylic acid) and carboxyl-terminated dendrimer

AU - Tomita, Shigeru

AU - Sato, Katsuhiko

AU - Anzai, Jun Ichi

PY - 2008/2/1

Y1 - 2008/2/1

N2 - Layer-by-layer (LbL) deposited thin films composed of poly(methacrylic acid) (PMAA) and poly(amide amine) dendrimer (PAMAM) were prepared and pH-induced decomposition was studied using a quartz crystal microbalance (QCM). The PMAA/PAMAM LbL films can be successfully prepared in the acidic solutions through hydrogen bonding and electrostatic interactions as driving forces. The LbL films are decomposed upon exposure to pH 5.5 or more basic solutions due to electrostatic repulsion between the carboxylate anions in PMAA and PAMAM. The usefulness of the thin films as pH-sensitive organic coatings in developing biosensors and drug delivery systems is suggested.

AB - Layer-by-layer (LbL) deposited thin films composed of poly(methacrylic acid) (PMAA) and poly(amide amine) dendrimer (PAMAM) were prepared and pH-induced decomposition was studied using a quartz crystal microbalance (QCM). The PMAA/PAMAM LbL films can be successfully prepared in the acidic solutions through hydrogen bonding and electrostatic interactions as driving forces. The LbL films are decomposed upon exposure to pH 5.5 or more basic solutions due to electrostatic repulsion between the carboxylate anions in PMAA and PAMAM. The usefulness of the thin films as pH-sensitive organic coatings in developing biosensors and drug delivery systems is suggested.

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KW - Carboxyl-terminated dendrimer

KW - Drug delivery

KW - Poly(methacrylic acid)

KW - pH-sensitive films

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pH-sensitive thin films compose of poly(methacrylic acid) and carboxyl-terminated dendrimer

Abstract

Keywords

ASJC Scopus subject areas

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