pH sensing by lipids in membranes: The fundamentals of pH-driven migration, polarization and deformations of lipid bilayer assemblies

Miglena I. Angelova, Anne Florence Bitbol, Michel Seigneuret, Galya Staneva, Atsuji Kodama, Yuka Sakuma, Toshihiro Kawakatsu, Masayuki Imai, Nicolas Puff

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

Most biological molecules contain acido-basic groups that modulate their structure and interactions. A consequence is that pH gradients, local heterogeneities and dynamic variations are used by cells and organisms to drive or regulate specific biological functions including energetic metabolism, vesicular traffic, migration and spatial patterning of tissues in development. While the direct or regulatory role of pH in protein function is well documented, the role of hydrogen and hydroxyl ions in modulating the properties of lipid assemblies such as bilayer membranes is only beginning to be understood. Here, we review approaches using artificial lipid vesicles that have been instrumental in providing an understanding of the influence of pH gradients and local variations on membrane vectorial motional processes: migration, membrane curvature effects promoting global or local deformations, crowding generation by segregative polarization processes. In the case of pH induced local deformations, an extensive theoretical framework is given and an application to a specific biological issue, namely the structure and stability of mitochondrial cristae, is described. This article is part of a Special Issue entitled: Emergence of Complex Behavior in Biomembranes edited by Marjorie Longo.

Original languageEnglish
Pages (from-to)2042-2063
Number of pages22
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1860
Issue number10
DOIs
Publication statusPublished - 2018 Oct

Keywords

  • Alzheimer's disease
  • Giant unilamellar vesicle
  • Lipid membrane dynamics
  • Local chemical gradient
  • Local chemical modification
  • Mitochondria

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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