PET study of cerebral glucose metabolism and fluorodopa uptake in patients with corticobasal degeneration

Haruo Nagasawa, Hiroaki Tanji, Hiroshi Nomura, Hiroshi Saito, Yasuto Itoyama, Itaru Kimura, Shoji Tuji, Takehiko Fujiwara, Ren Iwata, Masatoshi Itoh, Ido Tatsuo

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

We measured cerebral glucose utilization and fluorodopa metabolism in the brain of patients with corticobasal degeneration using positron emission tomography. The clinical pictures are distinctive, comprising features referable to both cerebral cortical and basal ganglionic dysfunctions. Brain images of glucose metabolism can demonstrate-specific abnormalities with a marked asymmetry in the parietal cortex (the primary motor and sensory cortex and the lateral parietal cortex); the thalamus, the caudate nucleus and the putamen of the dominantly affected hemisphere related to clinical symptoms in six patients. [18F]dopa uptake also reduced in an asymmetric pattern, both the caudate nucleus and the putamen in four patients. This unique combination study measuring both cerebral glucose utilization and fluorodopa metabolism in the nigrostriatal system can provide efficient information about the dysfunctions which are correlated with individual clinical symptoms.

Original languageEnglish
Pages (from-to)210-217
Number of pages8
JournalJournal of the neurological sciences
Volume139
Issue number2
DOIs
Publication statusPublished - 1996 Aug

Keywords

  • Cerebral metabolic rate of glucose
  • Corticobasal degeneration
  • Dopamine metabolism
  • Positron emission tomography

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'PET study of cerebral glucose metabolism and fluorodopa uptake in patients with corticobasal degeneration'. Together they form a unique fingerprint.

  • Cite this

    Nagasawa, H., Tanji, H., Nomura, H., Saito, H., Itoyama, Y., Kimura, I., Tuji, S., Fujiwara, T., Iwata, R., Itoh, M., & Tatsuo, I. (1996). PET study of cerebral glucose metabolism and fluorodopa uptake in patients with corticobasal degeneration. Journal of the neurological sciences, 139(2), 210-217. https://doi.org/10.1016/0022-510X(96)00057-3