PET kinetic analysis - Pitfalls and a solution for the Logan plot

Yuichi Kimura, Mika Naganawa, Miho Shidahara, Yoko Ikoma, Hiroshi Watabe

Research output: Contribution to journalReview articlepeer-review

32 Citations (Scopus)

Abstract

The Logan plot is a widely used algorithm for the quantitative analysis of neuroreceptors using PET because it is easy to use and simple to implement. The Logan plot is also suitable for receptor imaging because its algorithm is fast. However, use of the Logan plot, and interpretation of the formed receptor images should be regarded with caution, because noise in PET data causes bias in the Logan plot estimates. In this paper, we describe the basic concept of the Logan plot in detail and introduce three algorithms for the Logan plot. By comparing these algorithms, we demonstrate the pitfalls of the Logan plot and discuss the solution.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalAnnals of Nuclear Medicine
Volume21
Issue number1
DOIs
Publication statusPublished - 2007 Jan 1
Externally publishedYes

Keywords

  • Kinetic analysis
  • Logan plot
  • PET
  • Receptor imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint

Dive into the research topics of 'PET kinetic analysis - Pitfalls and a solution for the Logan plot'. Together they form a unique fingerprint.

Cite this