PET kinetic analysis: Error consideration of quantitative analysis in dynamic studies

Yoko Ikoma, Hiroshi Watabe, Miho Shidahara, Mika Naganawa, Yuichi Kimura

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

Positron emission tomography dynamic studies have been performed to quantify several biomedical functions. In a quantitative analysis of these studies, kinetic parameters were estimated by mathematical methods, such as a nonlinear least-squares algorithm with compartmental model and graphical analysis. In this estimation, the uncertainty in the estimated kinetic parameters depends on the signal-to-noise ratio and quantitative analysis method. This review describes the reliability of parameter estimates for various analysis methods in reversible and irreversible models.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalAnnals of Nuclear Medicine
Volume22
Issue number1
DOIs
Publication statusPublished - 2008 Jan 1
Externally publishedYes

Keywords

  • Compartmental model
  • Error analysis
  • PET

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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