Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice

Yuki Takayanagi, Masahide Yoshida, Isadora F. Bielsky, Heather E. Ross, Masaki Kawamata, Tatsushi Onaka, Teruyuki Yanagisawa, Tadashi Kimura, Martin M. Matzuk, Larry J. Young, Katsuhiko Nishimori

Research output: Contribution to journalArticle

481 Citations (Scopus)

Abstract

The oxytocin receptor (OXTR) and its ligand, oxytocin (OXT), regulate reproductive physiology (i.e., parturition and lactation) and sociosexual behaviors. To define the essential functions of OXTR, we generated mice with a null mutation in the Oxtr gene (Oxtr-/-) and compared them with OXT-deficient (Oxt-/-) mice. Oxtr-/- mice were viable and had no obvious deficits in fertility or reproductive behavior. Oxtr -/- dams exhibited normal parturition but demonstrated defects in lactation and maternal nurturing. Infant Oxtr-/- males emitted fewer ultrasonic vocalizations than wild-type littermates in response to social isolation. Adult Oxtr-/- males also showed deficits in social discrimination and elevated aggressive behavior. Ligand Oxt-/- males from Oxtr-/- dams, but not from Oxt+/- dams, showed similar high levels of aggression. These data suggest a developmental role for the OXT/OXTR system in shaping adult aggressive behavior. Our studies demonstrate that OXTR plays a critical role in regulating several aspects of social behavior and may have important implications for developmental psychiatric disorders characterized by deficits in social behavior.

Original languageEnglish
Pages (from-to)16096-16101
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume102
Issue number44
DOIs
Publication statusPublished - 2005 Nov 1

Keywords

  • Aggressive behavior
  • Lactation
  • Maternal behavior
  • Social discrimination
  • Ultrasonic vocalization

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice'. Together they form a unique fingerprint.

  • Cite this

    Takayanagi, Y., Yoshida, M., Bielsky, I. F., Ross, H. E., Kawamata, M., Onaka, T., Yanagisawa, T., Kimura, T., Matzuk, M. M., Young, L. J., & Nishimori, K. (2005). Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice. Proceedings of the National Academy of Sciences of the United States of America, 102(44), 16096-16101. https://doi.org/10.1073/pnas.0505312102