Persistent hypoglycemia induced by continuous insulin infusion in broiler chickens

Y. Akiba, Y. Chida, T. Takahashi, Y. Ohtomo, K. Sato, K. Takahashi

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

1. Persistent hypoglycaemia was experimentally induced by insulin infusion to improve understanding of the regulatory mechanisms of blood glucose concentrations specific to chickens. 2. An osmotic minipump containing bovine insulin was implanted to deliver insulin in vivo at a constant rate (11.25 to 45 U/kg BW/d) for 5 d in 4-week-old broiler chickens force-fed a maintenance diet once a d. Birds infused with the highest dose of insulin died within 3 to 4 d. 3. In chickens continuously infused with insulin at 22.5 U/kg BW/d, fasting glucose concentrations in plasma determined every 3 h during the 3rd day of infusion were consistently and significantly lower than in controls. 4. Continuous infusion of insulin at 22.5 U/kg BW/d induced persistent hypoglycaemia (almost one-half the normal blood glucose concentration) lasting for at least 4 d in broiler chickens. 5. Insulin infusion did not significantly change plasma NEFA or protein concentrations and increased plasma GOT activity only at 1 of the daily experimental sampling points.

Original languageEnglish
Pages (from-to)701-705
Number of pages5
JournalBritish Poultry Science
Volume40
Issue number5
DOIs
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Food Science
  • Animal Science and Zoology

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