Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer

Naoko Mori, Shunji Mugikura, Chiaki Takasawa, Minoru Miyashita, Akiko Shimauchi, Hideki Ota, Takanori Ishida, Atsuko kasajima, Kei Takase, Tetsuya Kodama, Shoki Takahashi

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Objectives: To evaluate whether visual assessment of T2-weighted imaging (T2WI) or an apparent diffusion coefficient (ADC) could predict lymphovascular invasion (LVI) status in cases with clinically node-negative invasive breast cancer. Materials and methods: One hundred and thirty-six patients with 136 lesions underwent MRI. Visual assessment of T2WI, tumour-ADC, peritumoral maximum-ADC and the peritumour-tumour ADC ratio (the ratio between them) were compared with LVI status of surgical specimens. Results: No significant relationship was found between LVI and T2WI. Tumour-ADC was significantly lower in the LVI-positive (n = 77, 896 ± 148 × 10−6 mm2/s) than the LVI-negative group (n = 59, 1002 ± 163 × 10−6 mm2/s; p < 0.0001). Peritumoral maximum-ADC was significantly higher in the LVI-positive (1805 ± 355 × 10−6 mm2/s) than the LVI-negative group (1625 ± 346 × 10−6 mm2/s; p = 0.0003). Peritumour-tumour ADC ratio was significantly higher in the LVI-positive (2.05 ± 0.46) than the LVI-negative group (1.65 ± 0.40; p < 0.0001). Receiver operating characteristic curve analysis revealed that the area under the curve (AUC) of the peritumour-tumour ADC ratio was the highest (0.81). The most effective threshold for the peritumour-tumour ADC ratio was 1.84, and the sensitivity, specificity, positive predictive value and negative predictive value were 77 % (59/77), 76 % (45/59), 81 % (59/73) and 71 % (45/63), respectively. Conclusions: We suggest that the peritumour-tumour ADC ratio can assist in predicting LVI status on preoperative imaging. Key points: • Tumour ADC was significantly lower in LVI-positive than LVI-negative breast cancer. • Peritumoral maximum-ADC was significantly higher in LVI-positive than LVI-negative breast cancer. • Peritumour-tumour ADC ratio was significantly higher in LVI-positive breast cancer. • Diagnostic performance of the peritumour-tumour ADC ratio was highest for positive LVI. • Peritumour-tumour ADC ratio showed higher diagnostic ability in postmenopausal than premenopausal patients.

Original languageEnglish
Pages (from-to)331-339
Number of pages9
JournalEuropean Radiology
Volume26
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1

Keywords

  • Beast Cancer
  • Diffusion-weighted MRI
  • Embolism
  • Lymphatic Vessels
  • Tumour

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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