Peripheral T-cell lymphoma with distinct perifollicular growth pattern: A distinct subtype of T-cell lymphoma?

T. Rüdiger, R. Ichinohasama, M. M. Ott, S. Müller-Deubert, I. Miura, G. Ott, H. K. Müller-Hermelink

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)


Nine cases of peripheral T-cell lymphoma were identified in this study showing a distinctive growth pattern with partial distortion of the lymph node structure and prominent infiltration predominantly of marginal zones by medium-sized cells with clear cytoplasm and significant nuclear atypia. In the paracortical T-zone, there was a marked proliferation of high endothelial venules. Plasmocytosis and capsular fibrosis were other distinctive features. On immunohistochemistry, the lymphomas proved to be of T-helper cell origin (CD3+. CD4, CD5(+/-), CD8-, TIA1-) and proliferation was most prominent in the marginal zone of the regressive B-cell follicles. These cases have a characteristic morphology that may be sufficient to differentiate them as a variant from other peripheral T-cell lymphomas of the 'not otherwise specified' group and to include them in the list of currently recognized lymphomas. Because of the distinct perifollicular growth pattern and incomplete effacemerit of the lymph node architecture, the differential diagnosis consists mainly of marginal zone B-cell lymphoma and reactive lesions.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalAmerican Journal of Surgical Pathology
Issue number1
Publication statusPublished - 2000 Jan


  • Immunohistochemistry
  • Lymphoma
  • Morphological variant
  • Peripheral
  • T-cell

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine


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