Peripheral airway hyperresponsiveness in the choline-deficiently fed rat

S. Itabashi, T. Ohrui, K. Sekizaw, Y. Matsuzaki, H. Sasaki

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    4 Citations (Scopus)

    Abstract

    Rats fed with choline-deficient diets are known as a model of aging and learning impairments due to acetylcholine (ACh) deficiency in the brain which may be associated with a decrease in acetylcholinesterase (AChE; EC 3.1.1.7). To determined the role of AChE in bronchial responsiveness, we examined the contractile response of isolated lung parenchymal strips to ACh in control rats and rats fed with choline-deficient diets. Concentration-response curves to ACh shifted to the lower concentrations and the maximum respose to ACh was greater in rats fed with choline-deficient diets than in control rats (P<0.01). Physostigmine (10-6 M) mimicked effects of choline-deficient diets on the contractile response to ACh. However, concentration response curves to carbachol and 5-hydroxytryptamine did not differ between control rats and rats fed with choline-deficient diets. Choline-deficient diets significantly decreased the AChE activity from homogenates of lung parenchymal tissues (P<0.01). These results suggest that a decrease in AChE activity of lung tissues may relate to airway hyperresponsiveness to ACh.

    Original languageEnglish
    Pages (from-to)219-225
    Number of pages7
    JournalRespiration Physiology
    Volume92
    Issue number2
    DOIs
    Publication statusPublished - 1993 May

    Keywords

    • Acetylcholinesterase
    • Airways
    • Hyperresponsiveness
    • Mammals
    • acetylcholinesterase deficiency
    • bronchi
    • bronchial responsiveness
    • bronchial smooth muscle
    • deficiency
    • hyperresponsiveness
    • rat

    ASJC Scopus subject areas

    • Physiology
    • Pulmonary and Respiratory Medicine

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