Periostin is a negative prognostic factor and promotes cancer cell proliferation in non-small cell lung cancer

Toshimasa Okazaki, Keiichi Tamai, Rie Shibuya, Mao Nakamura, Mai Mochizuki, Kazunori Yamaguchi, Jiro Abe, Satomi Takahashi, Ikuro Sato, Akira Kudo, Yoshinori Okada, Kennichi Satoh

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Periostin is a matricellular protein that is secreted by fibroblasts and interacts with various cell-surface integrin molecules. Although periostin is known to support tumor development in human malignancies, little is known about its effect on lungcancer progression. We here demonstrate that periostin is a negative prognostic factor that increases tumor proliferation through ERK signaling in non-small cell lung carcinoma. We classified 189 clinical specimens from patients with non-small cell lung-cancer according to high or low periostin expression, and found a better prognosis for patients with low rather than high periostin, even in cases of advancedstage cancer. In a syngenic implantation model, murine Ex3LL lung-cancer cells formed smaller tumor nodules in periostin-/- mice than in periostin+/+ mice, both at the primary site and at metastatic lung sites. An in vitro proliferation assay showed that stimulation with recombinant periostin increased Ex3LL-cell proliferation. We also found that periostin promotes ERK phosphorylation, but not Akt or FAK activation. These findings suggest that periostin represents a potential target in lung-cancer tumor progression.

Original languageEnglish
Pages (from-to)31187-31199
Number of pages13
JournalOncotarget
Volume9
Issue number58
DOIs
Publication statusPublished - 2018 Jul 27

Keywords

  • Cell proliferation
  • Lung cancer
  • Periostin
  • Prognosis
  • Prognostic factor

ASJC Scopus subject areas

  • Oncology

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