Periostin in the Cancer Stroma of Mycosis Fungoides Palmaris et Plantaris: A Case Report and Immunohistochemical Study

Kayo Tanita, Taku Fujimura, Aya Kakizaki, Sadanori Furudate, Masato Mizuashi, Akiko Watabe, Setsuya Aiba

Research output: Contribution to journalArticle

Abstract

Mycosis fungoides palmaris et plantaris (MFPP) is a rare variant of mycosis fungoides limited to the palms and soles. Although little is known about the pathogenesis of MFPP, this variant of mycosis fungoides presents a relatively good prognosis. In this report, we describe an 85-year-old Japanese man with MFPP. Immunohistochemical staining revealed the dense deposition of periostin in the cancer stroma, as well as infiltration of CD163+CD206- tumor-associated macrophages (TAMs), which suggested the phenotypes of TAMs were not polarized to the M2 phenotype in the lesional skin of MFPP. Our present case might suggest one of the possible reasons for the good prognosis of MFPP.

Original languageEnglish
Pages (from-to)31-35
Number of pages5
JournalCase Reports in Dermatology
Volume8
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

Keywords

  • M2 polarization
  • Mycosis fungoides palmaris et plantaris
  • Periostin
  • Prognosis
  • Tumor-associated macrophages

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'Periostin in the Cancer Stroma of Mycosis Fungoides Palmaris et Plantaris: A Case Report and Immunohistochemical Study'. Together they form a unique fingerprint.

  • Cite this