Periostin attenuates tumor growth by inducing apoptosis in colitisrelated colorectal cancer

Yusuke Shimoyama, Keiichi Tamai, Rie Shibuya, Mao Nakamura, Mai Mochizuki, Kazunori Yamaguchi, Yoichi Kakuta, Yoshitaka Kinouchi, Ikuro Sato, Akira Kudo, Tooru Shimosegawa, Kennichi Satoh

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Inflammatory bowel diseases, which are multifactorial autoimmune colitis diseases, are occurring with increasing prevalence. One of the most serious complications of these diseases is colorectal cancer. Here we investigated the role of periostin (Postn), a matricellular protein that interacts with various integrin molecules on the cell surface, in colitis-induced colorectal cancer. Immunohistochemistry of mouse and human colorectal cancer samples revealed that Postn was expressed in the stroma and was upregulated in close proximity to the cancer cells. The colonic tumorigenesis in an inflammation-related colon carcinogenesis mouse model was increased in Postn knock-out (Postn-/-) mice compared to Postn+/+ mice. Although no difference was found in the degree of colitis between Postn+/+ and Postn-/- mice, Postn inhibited tumor growth and induced the apoptosis of mouse rectal cancer cells in vitro. Furthermore, fewer apoptotic colorectal cancer cells were observed in Postn-/- than in Postn+/+ mice. These data suggested that Postn has an anti-tumor effect on colitis-induced colorectal cancer.

Original languageEnglish
Pages (from-to)20008-20017
Number of pages10
JournalOncotarget
Volume9
Issue number28
DOIs
Publication statusPublished - 2018 Apr 13

Keywords

  • Apoptosis
  • Colitis
  • Colorectal cancer
  • Periostin

ASJC Scopus subject areas

  • Oncology

Fingerprint Dive into the research topics of 'Periostin attenuates tumor growth by inducing apoptosis in colitisrelated colorectal cancer'. Together they form a unique fingerprint.

Cite this