Perinatal Exposure to Arsenic in Drinking Water Alters Glutamatergic Neurotransmission in the Striatum of C57BL/6 Mice

Kyunghwa Sung, Minjeong Kim, Haesoo Kim, Gi Wook Hwang, Kisok Kim

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Although exposure to arsenic (As) induces developmental neurotoxicity, there is a lack of data regarding its specific effects on glutamatergic neurotransmission in offspring from dams exposed to As during gestation and lactation. In this study, the body weight, glutamate content, and expression of vesicular glutamate transporter 2 (VGLUT2) and metabotropic glutamate receptors mGluR2 and mGluR3 was examined in the striatum of offspring following treatment of the dams with As (10 or 100 mg/L NaAsO 2 in drinking water). At postnatal day 21, body weight was decreased significantly, whereas the glutamate content in the striatum of offspring in the 100-mg/L As group were not significantly different from those in the control group. Although mGluR3 expression was not significantly different, VGLUT2 and mGluR2 expression was significantly lower in the striatum of offspring of As-exposed dams. These data indicate that altered glutamatergic neurotransmission may contribute to As-induced developmental neurotoxic effects.

Original languageEnglish
Pages (from-to)224-229
Number of pages6
JournalBiological Trace Element Research
Volume187
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1

Keywords

  • Arsenic
  • Glutamate
  • Striatum
  • VGLUT2
  • mGluR2
  • mGluR3

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Inorganic Chemistry

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