Perilesional treatment of metastatic melanoma with interferon-β

T. Fujimura; R. Okuyama; T. Ohtani; Y. Ito; T. Haga; A. Hashimoto; S. Aiba

doi:10.1111/j.1365-2230.2009.03207.x

Perilesional treatment of metastatic melanoma with interferon-β

T. Fujimura, R. Okuyama, T. Ohtani, Y. Ito, T. Haga, A. Hashimoto, S. Aiba

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Abstract

Previous trials with various treatments have not shown satisfactory therapeutic results for cutaneous metastasis of malignant melanoma (MM). We report three patients who were treated with peritumoral injection of interferon (IFN)-β for multiple skin metastases of MM. The metastatic tumours were infiltrated by significant numbers of CD8+ TIA+ cytotoxic lymphocytes, and the numbers of CD4+ cells and human leucocyte antigen-DR+ cells increased after IFN-β injection. These results suggest that the peritumoral administration of IFN-β enhanced the antitumour immune response against the MM, suggesting that it is a promising supportive treatment for skin metastasis of MM.

Original language	English
Pages (from-to)	793-799
Number of pages	7
Journal	Clinical and Experimental Dermatology
Volume	34
Issue number	7
DOIs	https://doi.org/10.1111/j.1365-2230.2009.03207.x
Publication status	Published - 2009 Oct

ASJC Scopus subject areas

Dermatology

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10.1111/j.1365-2230.2009.03207.x

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abstract = "Previous trials with various treatments have not shown satisfactory therapeutic results for cutaneous metastasis of malignant melanoma (MM). We report three patients who were treated with peritumoral injection of interferon (IFN)-β for multiple skin metastases of MM. The metastatic tumours were infiltrated by significant numbers of CD8+ TIA+ cytotoxic lymphocytes, and the numbers of CD4+ cells and human leucocyte antigen-DR+ cells increased after IFN-β injection. These results suggest that the peritumoral administration of IFN-β enhanced the antitumour immune response against the MM, suggesting that it is a promising supportive treatment for skin metastasis of MM.",

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AU - Fujimura, T.

AU - Okuyama, R.

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AU - Haga, T.

AU - Hashimoto, A.

AU - Aiba, S.

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N2 - Previous trials with various treatments have not shown satisfactory therapeutic results for cutaneous metastasis of malignant melanoma (MM). We report three patients who were treated with peritumoral injection of interferon (IFN)-β for multiple skin metastases of MM. The metastatic tumours were infiltrated by significant numbers of CD8+ TIA+ cytotoxic lymphocytes, and the numbers of CD4+ cells and human leucocyte antigen-DR+ cells increased after IFN-β injection. These results suggest that the peritumoral administration of IFN-β enhanced the antitumour immune response against the MM, suggesting that it is a promising supportive treatment for skin metastasis of MM.

AB - Previous trials with various treatments have not shown satisfactory therapeutic results for cutaneous metastasis of malignant melanoma (MM). We report three patients who were treated with peritumoral injection of interferon (IFN)-β for multiple skin metastases of MM. The metastatic tumours were infiltrated by significant numbers of CD8+ TIA+ cytotoxic lymphocytes, and the numbers of CD4+ cells and human leucocyte antigen-DR+ cells increased after IFN-β injection. These results suggest that the peritumoral administration of IFN-β enhanced the antitumour immune response against the MM, suggesting that it is a promising supportive treatment for skin metastasis of MM.

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Perilesional treatment of metastatic melanoma with interferon-β

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