Periampullary tumors: High-spatial-resolution MR imaging and histopathologic findings in ampullary region specimens

Reiji Sugita, Akemi Furuta, Kei Ito, Naotaka Fujita, Ryou Ichinohasama, Syouki Takahashi

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

PURPOSE: To prospectively determine the magnetic resonance (MR) signal intensity characteristics of structures of the ampullary region and to assess the potential use of MR imaging in evaluation of the extent of periampullary tumors in resected specimens. MATERIALS AND METHODS: Twenty-five specimens from the ampullary region obtained in four autopsy cases without periampullary tumors and in 21 patients with periampullary tumors were examined with a 1.5-T MR system and a circular surface coil with 5-inch (12.7-cm) diameter. High-spatial-resolution MR images were obtained with field of view of 100 × 100 mm, matrix of 256 × 256 or 512 × 256, and section thickness of 2 mm. MR imaging findings were compared with histopathologic findings. Sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of high-spatial-resolution MR imaging for assessment of tumor invasion into surrounding tissues were evaluated by two radiologists. RESULTS: T1- and T2-weighted MR images clearly depicted normal structures in the ampullary region that included Oddi muscle, duodenal wall, common bile duct, and pancreas; these findings corresponded well with histologic findings. In 20 (95%) of 21 tumors, high-spatial-resolution MR imaging depicted location and extension of periampullary tumors precisely. Sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of high-spatial-resolution MR imaging for assessment of tumor invasion into surrounding tissue were 88%, 100%, 96%, 100%, and 94%, respectively. CONCLUSION: In this study, MR imaging correctly depicted location, extension, and origin of tumor. High-spatial-resolution MR imaging has potential for presurgical staging of tumors in this region.

Original languageEnglish
Pages (from-to)767-774
Number of pages8
JournalRadiology
Volume231
Issue number3
DOIs
Publication statusPublished - 2004 Jun 1

Keywords

  • Bile ducts, neoplasms
  • Duodenum, neoplasms
  • Pancreas, neoplasms
  • Specimens, MR

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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