### Abstract

Purpose: To evaluate whether quantitative analysis of perfusion contrast-enhanced ultrasound (CE-US) could predict early lymph-node (LN) metastasis in clinically node-negative breast cancer. Materials and methods: In this prospective study, 64 breast cancer patients were selected for perfusion CE-US imaging. Regions of interest were placed where the strongest and weakest signal increases were found to obtain peak intensities (PIs; PI _{max} and PI _{min} , respectively) for time–intensity curve analyzes. The PI difference and PI ratio were calculated as follows: PI difference = PI _{max} −PI _{min} ; PI ratio = PI _{max} /PI _{min} . Results: Forty-seven cases were histologically diagnosed as negative for LN metastasis and 17 were positive. There was a significant difference in PI _{min} and the PI ratio between the LN-negative and -positive metastasis groups (p = 0.0053 and 0.0082, respectively). Receiver-operating curve analysis revealed that the area under the curve of PI _{min} and the PI ratio were 0.73 and 0.72, respectively. The most effective threshold for the PI ratio was 1.52, and the sensitivity, specificity, positive predictive value, and negative predictive value were 59% (10/17), 87% (41/47), 63% (10/16), and 85% (41/48), respectively. Conclusions: Parameters from the quantitative analysis of perfusion CE-US imaging showed significant differences between the LN-negative and -positive metastasis groups in clinically node-negative breast cancer.

Original language | English |
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Pages (from-to) | 145-153 |

Number of pages | 9 |

Journal | Japanese Journal of Radiology |

Volume | 37 |

Issue number | 2 |

DOIs | |

Publication status | Published - 2019 Feb 20 |

### Keywords

- Breast cancer
- Contrast-enhanced ultrasound
- Lymph-node metastasis
- Microbubble
- Ultrasound

### ASJC Scopus subject areas

- Radiology Nuclear Medicine and imaging

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## Cite this

*Japanese Journal of Radiology*,

*37*(2), 145-153. https://doi.org/10.1007/s11604-018-0792-6