Performance evaluation of the small-animal PET scanner ClairvivoPET using NEMA NU 4-2008 Standards

Kazuhiro Sato, Miho Shidahara, Hiroshi Watabe, Shoichi Watanuki, Yoichi Ishikawa, Y. Arakawa, Yh Nai, Shozo Furumoto, Manabu Tashiro, T. Shoji, Kazuhiko Yanai, Kohsuke Gonda

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The aim of this study was to evaluate the performance of ClairvivoPET using NEMA NU4 standards. The ClairvivoPET incorporates a LYSO dual depth-of-interaction detector system with 151 mm axial field of view (FOV). Spatial resolution, sensitivity, counting rate capabilities, and image quality were evaluated using NEMA NU4-2008 standards. Normal mouse imaging was also performed for 10min after intravenous injection of 18F(-)-NaF. Data were compared with 19 other preclinical PET scanners. Spatial resolution measured using full width at half maximum on FBP-ramp reconstructed images was 2.16 mm at radial offset 5 mm of the axial centre FOV. The maximum absolute sensitivity for a point source at the FOV centre was 8.72%. Peak noise equivalent counting rate (NECR) was 415kcps at 14.6MBq ml-1. The uniformity with the image-quality phantom was 4.62%. Spillover ratios in the images of air and water filled chambers were 0.19 and 0.06, respectively. Our results were comparable with the 19 other preclinical PET scanners based on NEMA NU4 standards, with excellent sensitivity because of the large FOV. The ClairvivoPET with iterative reconstruction algorithm also provided sufficient visualization of the mouse spine. The high sensitivity and resolution of the ClairvivoPET scanner provided high quality images for preclinical studies.

Original languageEnglish
Pages (from-to)696-711
Number of pages16
JournalPhysics in Medicine and Biology
Volume61
Issue number2
DOIs
Publication statusPublished - 2015 Dec 30

Keywords

  • ClairvivoPET
  • NEMA NU 4-2008
  • Small animal PET scanner

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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