Peptidoglycan recognition proteins in Drosophila immunity

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111 Citations (Scopus)

Abstract

Innate immunity is the front line of self-defense against infectious non-self in vertebrates and invertebrates. The innate immune system is mediated by germ-line encoding pattern recognition molecules (pathogen sensors) that recognize conserved molecular patterns present in the pathogens but absent in the host. Peptidoglycans (PGN) are essential cell wall components of almost all bacteria, except mycoplasma lacking a cell wall, which provides the host immune system an advantage for detecting invading bacteria. Several families of pattern recognition molecules that detect PGN and PGN-derived compounds have been indentified, and the role of PGRP family members in host defense is relatively well-characterized in Drosophila. This review focuses on the role of PGRP family members in the recognition of invading bacteria and the activation and modulation of immune responses in Drosophila.

Original languageEnglish
Pages (from-to)36-41
Number of pages6
JournalDevelopmental and Comparative Immunology
Volume42
Issue number1
DOIs
Publication statusPublished - 2014 Jan

Keywords

  • Antimicrobial defense
  • Drosophila
  • Innate immunity
  • Pattern recognition receptor
  • Peptidoglycan recognition protein
  • Prophenoloxidase cascade

ASJC Scopus subject areas

  • Immunology
  • Developmental Biology

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