Peptide drug release behavior from biodegradable temperature-responsive injectable hydrogels exhibiting irreversible gelation

Kazuyuki Takata, Hiroki Takai, Yuta Yoshizaki, Takuya Nagata, Keisuke Kawahara, Yasuyuki Yoshida, Akinori Kuzuya, Yuichi Ohya

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the release behavior of glucagon-like peptide-1 (GLP-1) from a biodegradable injectable polymer (IP) hydrogel. This hydrogel shows temperature-responsive irreversible gelation due to the covalent bond formation through a thiol-ene reaction. In vitro sustained release of GLP-1 from an irreversible IP formulation (F(P1/D+PA40)) was observed compared with a reversible (physical gelation) IP formulation (F(P1)). Moreover, pharmaceutically active levels of GLP-1 were maintained in blood after subcutaneous injection of the irreversible IP formulation into rats. This system should be useful for the minimally invasive sustained drug release of peptide drugs and other water-soluble bioactive reagents.

Original languageEnglish
Article number38
JournalGels
Volume3
Issue number4
DOIs
Publication statusPublished - 2017 Dec
Externally publishedYes

Keywords

  • Hydrogel
  • Injectable polymers
  • Peptide drug delivery
  • Sol-to-gel transition
  • Sustained release

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Organic Chemistry
  • Polymers and Plastics

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