The α-helix structures of the anti-HIV fusion inhibitory peptides are stabilized by the amino acid sequence and by intrachain hydrogen bonds. The study of peptide analogues using (E)-alkene and (Z)-fluoroalkene dipeptide isosteres demonstrated the substantial, yet position-dependent, contribution of hydrogen bonds to the α-helix stability and anti-HIV bioactivity.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry