Pembrolizumab resolves adult ashy dermatosis developing in patients with squamous cell carcinoma of the lung

Kana Takeda, Taku Fujimura, Kenichiro Tsuchiyama, Chunbing Lyu, Setsuya Aiba

Research output: Contribution to journalArticlepeer-review

Abstract

Ashy dermatosis is a rare cutaneous disorder of unknown etiology. We describe a case of adult ashy dermatosis developing in a patient with squamous cell carcinoma of the lung, which was resolved by the administration of pembrolizumab in parallel with multiple vitiligo. Interestingly, immunohistochemical staining revealed that lesional skin of the ashy dermatosis contained cytotoxic T cells and programmed death ligand 1 expressing cells. To our knowledge, this is the first case of adult ashy dermatosis resolved by pembrolizumab.

Original languageEnglish
Pages (from-to)271-273
Number of pages3
JournalJournal of Dermatology
Volume46
Issue number3
DOIs
Publication statusPublished - 2019 Mar

Keywords

  • ashy dermatosis
  • autoreactive T cells
  • pembrolizumab
  • programmed death 1/programmed death ligand 1 signaling
  • vitiligo

ASJC Scopus subject areas

  • Dermatology

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