TY - JOUR
T1 - Pembrolizumab resolves adult ashy dermatosis developing in patients with squamous cell carcinoma of the lung
AU - Takeda, Kana
AU - Fujimura, Taku
AU - Tsuchiyama, Kenichiro
AU - Lyu, Chunbing
AU - Aiba, Setsuya
PY - 2019/3
Y1 - 2019/3
N2 - Ashy dermatosis is a rare cutaneous disorder of unknown etiology. We describe a case of adult ashy dermatosis developing in a patient with squamous cell carcinoma of the lung, which was resolved by the administration of pembrolizumab in parallel with multiple vitiligo. Interestingly, immunohistochemical staining revealed that lesional skin of the ashy dermatosis contained cytotoxic T cells and programmed death ligand 1 expressing cells. To our knowledge, this is the first case of adult ashy dermatosis resolved by pembrolizumab.
AB - Ashy dermatosis is a rare cutaneous disorder of unknown etiology. We describe a case of adult ashy dermatosis developing in a patient with squamous cell carcinoma of the lung, which was resolved by the administration of pembrolizumab in parallel with multiple vitiligo. Interestingly, immunohistochemical staining revealed that lesional skin of the ashy dermatosis contained cytotoxic T cells and programmed death ligand 1 expressing cells. To our knowledge, this is the first case of adult ashy dermatosis resolved by pembrolizumab.
KW - ashy dermatosis
KW - autoreactive T cells
KW - pembrolizumab
KW - programmed death 1/programmed death ligand 1 signaling
KW - vitiligo
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U2 - 10.1111/1346-8138.14775
DO - 10.1111/1346-8138.14775
M3 - Article
C2 - 30663147
AN - SCOPUS:85060338995
VL - 46
SP - 271
EP - 273
JO - Journal of Dermatology
JF - Journal of Dermatology
SN - 0385-2407
IS - 3
ER -