Peer attachment formation by systemic redox regulation with social training after a sensitive period

Mamiko Koshiba, Genta Karino, Aya Senoo, Koki Mimura, Yuka Shirakawa, Yuta Fukushima, Saya Obara, Hitomi Sekihara, Shimpei Ozawa, Kentaro Ikegami, Toyotoshi Ueda, Hideo Yamanouchi, Shun Nakamura

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Attachment formation is the most pivotal factor for humans and animals in the growth and development of social relationships. However, the developmental processes of attachment formation mediated by sensory-motor, emotional, and cognitive integration remain obscure. Here we developed an animal model to understand the types of social interactions that lead to peer-social attachment formation. We found that the social interaction in a sensitive period was essential to stabilise or overwrite the initially imprinted peer affiliation state and that synchronised behaviour with others based on common motivations could be a driver of peer social attachment formation. Furthermore, feeding experience with supplementation of ubiquinol conferred peer social attachment formation even after the sensitive period. Surprisingly, the experience of feeding beyond the cage window was also effective to reduce the required amount ubiquinol, suggesting that peri-personal space modulation may affect socio-emotional cognition and there by lead to attachment formation.

Original languageEnglish
Article number2503
JournalScientific reports
Publication statusPublished - 2013
Externally publishedYes

ASJC Scopus subject areas

  • General


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