PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene

E. Ogawa, M. Maruyama, H. Kagoshima, M. Inuzuka, J. Lu, M. Satake, K. Shigesada, Y. Ito

Research output: Contribution to journalArticlepeer-review

551 Citations (Scopus)

Abstract

cDNAs representing the α subunit of polyomavirus enhancer binding protein 2 (PEBP2; also called PEA2) were isolated. The products of the cDNAs are highly homologous to that of Drosophila segmentation gene runt (run) for an N-proximal 128-amino acid region showing 66% identity. The run homology region encompasses the domain capable of binding to a specific nucleotide sequence motif and of dimerizing with the companion β subunit. The human AML1 gene related to t(8;21) acute myeloid leukemia also has a run homology region. Together with the β subunit, which increases the affinity of the α subunit to DNA without binding to DNA by itself, PEBP2 represents a newly discovered family of transcription factor. The major species of PEBP2α mRNA was expressed in T-cell lines but not in B-cell lines tested. Evidence indicated that PEBP2 functions as a transcriptional activator and is involved in regulation of T-cell-specific gene expression.

Original languageEnglish
Pages (from-to)6859-6863
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number14
DOIs
Publication statusPublished - 1993

Keywords

  • DNA binding and dimerization domain
  • T-cell receptor
  • acute myeloid leukemia
  • early development
  • t(8;21)

ASJC Scopus subject areas

  • General

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