Pdi family members as guides for client folding and assembly

Shingo Kanemura, Motonori Matsusaki, Kenji Inaba, Masaki Okumura

Research output: Contribution to journalReview articlepeer-review

Abstract

Complicated and sophisticated protein homeostasis (proteostasis) networks in the endoplasmic reticulum (ER), comprising disulfide catalysts, molecular chaperones, and their regulators, help to maintain cell viability. Newly synthesized proteins inserted into the ER need to fold and assemble into unique native structures to fulfill their physiological functions, and this is assisted by protein disulfide isomerase (PDI) family. Herein, we focus on recent advances in understanding the detailed mechanisms of PDI family members as guides for client folding and assembly to ensure the efficient production of secretory proteins.

Original languageEnglish
Article number9351
Pages (from-to)1-20
Number of pages20
JournalInternational journal of molecular sciences
Volume21
Issue number24
DOIs
Publication statusPublished - 2020 Dec 2

Keywords

  • Assembly
  • Disassembly
  • Disulfide
  • Endoplasmic reticulum (ER)
  • Protein disulfide isomerase (PDI) family
  • Protein folding
  • Redox

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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