Pctaire1/Cdk16 promotes skeletal myogenesis by inducing myoblast migration and fusion

Kouhei Shimizu, Atsushi Uematsu, Yuuki Imai, Tatsuya Sawasaki

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The Cdk-related protein kinase Pctaire1/Cdk16 is abundantly expressed in brain, testis and skeletal muscle. Functional roles of Pctaire1 such as regulation of neuron migration and neurite outgrowth thus far have been mainly elucidated in the field of nervous system development. Although these regulations based on cytoskeletal rearrangements evoke a possible role of Pctaire1 in the development of skeletal muscle, little is known in this regard. In this study, we demonstrated that myogenic differentiation and subsequent fusion is promoted in Pctaire1 overexpressing cells, and conversely, is inhibited in the knockdown cells. Furthermore, our findings suggest that Pctaire1 exerts promyogenic effects by regulating myoblast migration and process formation during skeletal myogenesis.

Original languageEnglish
Pages (from-to)3030-3037
Number of pages8
JournalFEBS Letters
Volume588
Issue number17
DOIs
Publication statusPublished - 2014 Aug 25

Keywords

  • Migration
  • Pctaire1/Cdk16
  • Process formation
  • Skeletal muscle differentiation

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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